Heat oven to 375 degrees F.
Lay barramundi fillets in a single layer in a medium baking dish.
In a medium mixing bowl, whisk together garlic, white wine, melted butter, lemon juice, capers, salt and pepper.
Pour sauce over barramundi. Spoon the sauce over top of the fish a few times to make sure that it’s evenly coated.
Bake at 375 degrees F for 15-18 minutes until the fish is bright white, opaque, and easily flakes with a fork.